Method comparison of antibody titre sensitivity using RCPAQAP datasets

Introduction: The antibody titre offered by the Royal College of Pathologists Australasia Quality Assurance Programs (RCPAQAP) surveys laboratory technical procedures on titres using various methods. A review is performed reports last 5 years to ascertain any differences in sensitivity between methods employed laboratories. Method: Titre results were extrapolated from 20 samples over years. are categorised into manual tube technique and card technologies. Any significant bias was determined comparing medians methods, which directly correlates method sensitivity. also compared higher dilution targets determine linear relationship. Conclusion: Across all survey samples, found have similar, or nine instances, one median lower than Mean be significantly (p<0.05). This relationship consistent previous literature.1,2 may implications with across different groups a context, however there procedural external factors that contribute this variance must considered. References 1. Lieberman L, Andrews J, Evans MD, et al. Comparison prenatal anti-D titration testing gel methods: literature. Transfusion 2021; 61: 1749–1756. 2. Novaretti MCZ, Jens E, Pagliarini T, conventional test diamed microcolumn assay for titration. Clin Lab Haematol 2003; 25: 311–315.